Strategic Leadership & Program Oversight

· Develop and execute a comprehensive drug discovery strategy, aligning with corporate objectives.

· Lead multiple early-stage programs, from target validation through IND-enabling studies.

· Identify, assess, and validate novel therapeutic targets and drug candidates.

· Establish key milestones and decision gates for advancing programs.

Preclinical Research & Development

· Oversee in vitro and in vivo pharmacology efforts, including: (1) Target engagement, mechanism of action studies, biomarker identification; (2) in vivo efficacy, safety, and PK/PD profiling; and (3) disease model development and validation.

· Guide medicinal chemistry, protein engineering, or other modality-specific optimization.

· Ensure integration of AI/ML-driven approaches, automation, or high-throughput screening (if applicable).

External Partnerships & Collaborations

· Manage relationships with CROs, academic partners, and biotech collaborators to accelerate R&D programs.

· Scout and implement new technologies for enhancing discovery efforts.

· Engage with regulatory authorities, investors, and industry partners as needed.

Cross-Functional Coordination

· Work closely with CMC, regulatory, and clinical teams to transition drug candidates into development.

· Contribute to regulatory filings, including IND submissions and briefing packages.

· Maintain compliance with industry regulations and best practices.

Team Leadership & Mentorship

· Build and lead a high-performing scientific research team.

· Mentor junior scientists and research associates in experimental design and data interpretation.

· Foster a culture of scientific excellence, collaboration, and innovation.

· PhD or MD/PhD in Pharmacology, Molecular Biology, Biochemistry, Medicinal Chemistry, or a related field.

· 10+ years of experience in drug discovery and preclinical development, with at least 5 years in a leadership role.

· Proven track record of leading programs from hit-to-lead optimization through IND-enabling studies.

· Experience with invivo model or/and translational science.

· Knowledge of GLP and regulatory requirements for IND-enabling studies.

· Familiarity with high-throughput screening, AI/ML-driven drug discovery, or computational biology is a plus.

· Ability to work in a fast-paced startup/biotech environment.

At VRG Therapeutics, we value diversity and are committed to creating an inclusive workplace where all voices are heard. We welcome applicants of all backgrounds and encourage individuals with diverse experiences to apply. If you need accommodations during the hiring process, please let us know.